Article Sidebar

Published: 2012-03-30
Abstract Views: 61
DOI: https://doi.org/10.53747/nst.v2i1.275
Issue
Vol. 2 No. 1 (2012)
Section
Articles
How to Cite
TRAN , B. D., TRAN , M. Q., HOANG , D. S., PHAM , Q. H., HOANG , P. T., NGUYEN , V. B., PHAM , D. D., & NGUYEN , T. H. T. (2012). STUDY ON DEGRADATION OF SILK FIBROIN BY IRRADIATION TREATMENT FOR COSMETIC AND PHARMACEUTICAL APPLICATIONS. Nuclear Science and Technology, 2(1), 43-50. https://doi.org/10.53747/nst.v2i1.275

STUDY ON DEGRADATION OF SILK FIBROIN BY IRRADIATION TREATMENT FOR COSMETIC AND PHARMACEUTICAL APPLICATIONS

TRAN BANG DIEP1, TRAN MINH QUYNH1, HOANG DANG SANG1, PHAM QUANG HIEU1, HOANG PHUONG THAO1, NGUYEN VAN BINH1, PHAM DUY DUONG1, NGUYEN THUY HUONG TRANG1
1 Hanoi Irradiation Centre, Minh Khai - Tu Liem - Hanoi

Main Article Content

Abstract

As a kind of protein, silk fibroin is created with silkworm Bombyx mori in products of silk. The fibroin was irradiated using Co-60 gamma source and its degradability and solubility were investigated with various radiation doses to apply in pharmacy and cosmetic. Addition to the morphological changes of irradiated fibroin fibers shows that its mechanical properties were much influenced by the irradiation. Tensile strength and elongation at break of the silk fibroin significantly decreased with increasing of radiation dose up to 1000kGy. The tensile strength and elongation at break of the irradiated fibroin at 1000kGy reduced to 71% and 94% respectively in compared with non-irradiated one. The solubility of silk fibroin in both calcium chloride (CaCl2/C2H5OH/H2O=1:2:8) in mole ratio and distilled water were improved by the irradiation. UV spectrometry revealed the structure of silk fibroin was also changed by irradiation.

Article Details

Keywords

Silk, Fibroin, Radiation Degradation, Dissolution

References

1. Altman, G. H., Diaz, F., Jakuba, C., Calabro, T., Horan, R. L ., Chen, J., Lu, H., Richmond., Kaplan, D.L. Silk-based biomaterials. Biomaterials. 2003, 24, 401- 416.
2. ASTM D 1294-2005: Test method for tensile strength and breaking tenacity of wool fiber bundles 1 in.
3. Byun, E. B., Sung, N. Y., Kim, J. H., Choi, J. I., Matsui, T., Byun, M. W., and Lee, J. W. Enhancement of anti-tumor activity of gamma-irradiated silk fibroin via immunomodulatory effects. Chemico-Biological Interactions. 2010, 186, 90-95.
4. Cao, Y.; Wang, B. Biodegradation of silk biomaterials. Int. J. Mol. Sci. 2009, 10, 1514-1524.
5. Ishida, K.; Takeshita, H.; Kamiishi, Y.; yoshi, F.; Kume, T. Radiation degradation of silk. Jaeri-conf. 2001, 005, 130-138.
6. Kim U., Park J., Li Ch., Jin H., Valluzzi R. and Kaplan D. L. Structure and Properties of Silk Hydrogels. Biomacromolecules. 2004, 5, 786-792.
7. Pewlong, W., Sudatis, B., Takeshita, H., Yoshii, F., Kume, T. Radiation degradation of silk protein. In: Proceedings of JAERI Conference 2000-2003, Takasaki, Japan, pp. 146-152.
8. Sudatis, B. and Pongpat, S. Solubilization of Silk Protein by Radiation. Nippon Genshiryoku Kenkyujo JAERI, Conf. 2002, 101-104.
9. Yao, W.; Liu, Z.; Yi, H.; Wang, J. Structure and mechanical property of silk fiber under gamma radiation.Trans tech publications. 2011, 85, 175-176.
10. Zhao, Y.; Yan, X.; Ding, F.; Yang, Y.; Gu, X. The effects of different sterilization methods on silk fibroin. J.Biomedical Science and Engineering. 2011, 4, 397-402.